New research indicates that patients who stop using popular GLP-1 drugs like semaglutide or tirzepatide can put back on shed pounds at a significantly accelerated pace than those who stop conventional lifestyle plans.
Findings released in a prominent medical journal points out that while overweight people can lose a large proportion of their body weight while undergoing treatment, the mass returns at an estimated rate of nearly a kilo each month after stopping.
"People using such medications need to be cognizant of the danger of rapid weight regain when the medication ends," cautioned researcher Dr. Susan Jebb.
This pace of recovery means a reversion to pre-treatment weight in about 18 months.
Weighing Approaches
The research, which looked at dozens of studies involving thousands of participants, contrasted the results of the injectable medications with other pills.
The team point out that individuals who shed pounds through diet and exercise typically experience a more gradual weight regain—perhaps 0.1 kg a month—once they finish.
Understanding the Quick Regain
Nutrition scientists suggest the mode of action of the jabs accounts for the accelerated rebound.
These medications mimic a natural hormone called glucagon-like peptide-1, which moderates hunger.
"Long-term administration of GLP-1 levels several times higher than the body's typical production might result in the body to produce less of its own natural hormone, and may also diminish responsiveness to its effects," noted Dr. Adam Collins, a dietetics expert.
"Stopping of this hormone supplement leads to hunger is unsuppressed, making binge eating a significant risk."
An Ongoing Condition?
The NHS recommend the injections for people with weight-linked health risks, accompanied by recommended diet and exercise modifications.
Professionals contend that, considering the high risk of relapse, the treatment is often long-term.
This view is reinforced by pharmaceutical companies, who note that the findings "underscore the chronic character of obesity," akin to managing conditions like diabetes.
Patient Experiences
Individuals who have discontinued the medication report a sudden return of hunger.
"It felt as if something that goes on and you're instantly starving," described an individual.
This challenge is worsened if individuals have not adopted permanent lifestyle or habit changes during therapy.
Growing Adoption
Figures suggest that a significant number of people in the UK have tried these injections in the past year, with desire continuing to grow.
- Use is greater among females compared to men.
- The 40s and 50s demographic shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
In conclusion, experts stress that while GLP-1 drugs are potent tools for shedding pounds, they are not a magic cure and lasting health benefits relies on integrated behavioural support.
